HORDB

ID: hor005165
Uniprot ID: P83683
Protein name: Orexigenic neuropeptide 26RFa
Gene name: NA
Organism: Pelophylax lessonae (Pool frog) (Rana lessonae)
Family: RFamide neuropeptide family
Source: animal
Expression: Brain.
Disease: NA
Comments: NA
Taxonomy: Pelophylax (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity; GO:0031854 orexigenic neuropeptide QRFP receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005575 cellular_component; GO:0005576 extracellular region

Function: May have orexigenic activity and act as a hypophysiotropic neurohormone. This neuropeptide is involved in the control of feeding behavior.
Mechanism: It activates adenylyl cyclase activity in rat pituitary cells
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P83683-F1.pdb

hor005165_AF2.pdb

hor005165_ESM.pdb

Mass:	326526	Formula:	C127H196N36O37
Absent amino acids:	CDHIMPQW	Common amino acids:	G
pI:	10.24	Basic residues:	4
Polar residues:	11	Hydrophobic residues:	9
Hydrophobicity:	-33.85	Boman Index:	-4129
Half-Life:	100 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	63.85
Instability Index:	805.77	Extinction Coefficient cystines:	1490
Absorbance 280nm:	59.6

PubMed ID: 14657341
Title: Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity.